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The San Francisco 49ers will look to continue their winning ways on Thursday night when the New York Giants visit Levi’s Stadium. The 49ers (2-0) limited the Los Angeles Rams to a pair of second-half field goals last week to remain unbeaten, while the Giants (1-1) climbed out of a 20-0 hole with 31 points over the final two quarters to notch their first win of the season.

Notable Matchups
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The Detroit Lions (1-1) will host the surprising Atlanta Falcons (2-0) in an intriguing matchup at Ford Field. The Lions are a 3.5-point favorite but have surrendered a whopping 28.5 points per game. The Falcons boast the league’s fourth-ranked rushing attack and an improved defensive unit, allowing the third-fewest total yards.
The Minnesota Vikings (0-2) and Los Angeles Chargers (0-2) will meet at U.S. Bank Stadium in a must-win contest for both squads. The Chargers are a 1-point road favorite but are winless despite sporting a high-powered offense that averages 414 yards per game. The Vikings acquired Cam Akers this week to upgrade the league’s worst rushing attack.
In an early AFC East showdown, the New England Patriots (0-2) will travel to MetLife Stadium to battle the New York Jets (1-1). The Patriots are a 2.5-point road favorite and are looking to avoid a 0-3 start for the first time in over two decades. The Jets are struggling mightily on offense without Aaron Rodgers and tallied 215 total yards in a loss to the Cowboys in Week 2.
The Washington Commanders (2-0) will be seeking their best start since 2005 when the Buffalo Bills (1-1) visit FedEx Field on Sunday. The Bills are a 6.5-point road favorite and trot out the league’s eight-ranked scoring offense. Last week, the Commanders overcame a 21-3 deficit to stun the Denver Broncos in a high-scoring affair.
Upset of the Week
The Miami Dolphins (2-0) topped the New England Patriots last week to remain unbeaten and will host the winless Denver Broncos (0-2) on Sunday. The Dolphins are a 6.5-point home favorite, but Denver needs a win in a bad way and will deal Miami its first setback of the season.
Monday Night Doubleheader
Something will have to give when the Tampa Bay Buccaneers (2-0) and the Philadelphia Eagles (2-0) tangle on Monday night at Raymond James Stadium. The Eagles are a 4.5-point road favorite and sports the NFL’s second-ranked rushing attack, while the Buccaneers boast the league’s No. 2 run defense.
The Cincinnati Bengals (0-2) and the Los Angeles Rams (1-1) will clash Monday night in an exciting matchup at Paycor Stadium. The Bengals are a 2.5-point favorite and desperately need a win to avoid their first 0-3 starts since 2019. The Rams high-octane offense averages 414 total yards per game, including 320.5 passing yards.
NFL Week 3 Full Schedule (All times Eastern)
Thursday, Sept. 21
• San Francisco 49ers vs. New York Giants, 8:15 p.m. (Prime Video)
Sunday, Sept. 24
• Cleveland Browns vs. Tennessee Titans, 1 p.m. (CBS)
• Detroit Lions vs. Atlanta Falcons, 1 p.m. (CBS)
• Green Bay Packers vs. New Orleans Saints, 1 p.m. (FOX)
• Miami Dolphins vs. Denver Broncos, 1 p.m. (CBS)
• Minnesota Vikings vs. Los Angeles Chargers, 1 p.m. (FOX)
• New Yorks Jets vs. New England Patriots, 1 p.m. (CBS)
• Washington Commanders vs. Buffalo Bills, 1 p.m. (CBS)
• Jacksonville Jaguars vs. Houston Texans, 1 p.m. (FOX)
• Baltimore Ravens vs. Indianapolis Colts, 1 p.m. (CBS)
• Seattle Seahawks vs. Carolina Panthers, 4:05 p.m. (CBS)
• Kansas City Chiefs vs. Chicago Bears, 4:25 p.m. (FOX)
• Arizona Cardinals vs. Dallas Cowboys, 4:25 p.m. (FOX)
• Las Vegas Raiders vs. Pittsburgh Steelers, 8:20 p.m. (NBC)
Monday, Sept. 25
• Tampa Bay Buccaneers vs. Philadelphia Eagles, 7:15 p.m. (ABC)
• Cincinnati Bengals vs. Los Angeles Rams, 8:15 p.m. (ESPN)
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