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Philadelphia Eagles vs San Francisco 49ers Prediction, Odds and Betting Lines (09/19/2021)

Kyle Shanahan really had to sweat the victory against Detroit in the opening week and now his team is going on a second road trip – this time versus Philadelphia. Jalen Hurts and his Eagles mopped the floor with Atlanta’s defense and hung 32 on them. How are the betting lines looking here, are there any good picks on the game, and do we recommend betting anything – read below.

Eagles vs 49ers: Our best bet is the spread – Eagles + 3.5 @ -110

This is a classic flat spot for the 49ers, and we are giving an advantage to the Eagles. San Francisco had to fly all the way back home from Detroit and will have to travel back to Philadelphia for this match. What’s more interesting is the fact that the 49ers have a so-called ‘’look-ahead’’ game against the Green Packers in week 3.

Another thing that shouldn’t be underestimated is that the atmosphere at Lincoln Financial will be absolutely electric. This is the first game with fans in the stands since the 2019/2020 season and this place will be wild. It will surely make it tough for Kyle Shanahan’s clockwork offense to work well.

We also saw the 49ers’ defense allowing 430 yards to a team that has one good tight end and two decent running backs. The right side here is the home underdog at -110.

Make your wager here >>>

Is the total on the Philadelphia vs San Francisco game looking good?

It is a pretty high total at 50.5 and we think these two teams won’t reach it. Yes, San Francisco currently ranks 1st in scoring with 41 points per game and the Eagles are 9th with 32.

However, this Philly defense allowed only 6 points on the road in the opener. Was that a fluke? They were facing a high-powered (at least on paper) Atlanta offense with an offensive head coach in Arthur Smith’s face.

The 49ers’ defense actually recorded a pick-six which additionally bumped last week’s score. Our experts think that this will be a little more of a defensive battle than an offensive one and thus we are picking the total score to go under 50.5 points @ -110.

Make your wager here >>>

Players to watch in the PHI vs SF match

Jimmy Garoppolo: The 49ers’ QB is going to be under close inspection all season long. Many people speculate that the coaches start him only to increase his price and to have him traded by the deadline. Garoppolo fumbled the 1st snap of the game last week and was taken out once in the red zone when Trey Lance went in and threw a touchdown pass. Jimmy G has no margin for error.

Brandon Graham: The big defensive end for the Eagles will be fun to watch against the light but the quick offensive line of the 49ers. He recorded 2 tackles and 1 TFL last week so the odds for a sack here will not be slim. Expect him to create plenty of pressure.

Our Bonus picks for that match

  1. Team to score longest touchdown: PHI Eagles @ +100
  2. Team Filed goals scored: SF 49ers – Over 1.5 @ -150
  3. Winning margin: Eagles 1-6 @ +400

Make your wager here >>>


Philadelphia Eagles vs San Francisco 49ers Prediction

Frequently asked questions about the Eagles vs 49ers game

  • Where can I bet the match? – We recommend betting with Caesars NJ.
  • Will Trey lance play? – He will not be the starter against the Eagles but may be subbed in at any time.


About the author

Zack TC

Zack is a long-time NFL fan and writer who also enjoys fantasy football in his free time. His experience with the game of football includes not only writing analysis but also playing the game as a quarterback in the past and currently being an offensive playcaller for a local team.