Indianapolis Colts vs Los Angeles Rams prediction and odds

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The Los Angeles Rams travel to take on the Indianapolis Colts, who are a surprising 2-1 and getting rookie quarterback Anthony Richardson back from a concussion. But he could be in trouble against Aaron Donald.

Indianapolis Colts vs Los Angeles Rams – Game predictions

Contents

1 Indianapolis Colts vs Los Angeles Rams – Game predictions
2 Colts vs Rams preview – Which offensive line holds up?
3 Key match details

The Colts are a 1-point home favorite with a total of 45 points. You can find the spread as a pick ‘em at some sportsbooks due to the health uncertainty among the Indianapolis offensive line.

Prediction 1: Rams ML @ -110 (1.91)

The Colts had a great upset in Baltimore last week, but they showed some cracks in that game with pass protection and the offense wasn’t that productive. While Richardson’s return should help, he does not have a good line in front of him, which could be trouble against Aaron Donald. Matthew Stafford can bounce back from Week 3’s loss in Cincinnati, and rookie Puka Nacua looks like the real deal in this offense. Sean McVay has the coaching experience and will not let his team lose a third in a row here. Take the Rams to win.

Prediction 2: Matthew Stafford over 254.5 passing yards @ -115 (1.87)

Stafford should get a lot of passing opportunities in a game script that could see this turn into a shootout, or he could have to carry the offense with the running game getting shut down. Either way, he has solid weapons around him even without Cooper Kupp thanks to the improvement of Tutu Atwell and the unbelievable job by rookie Puka Nacua. The Colts allowed Lamar Jackson to go over 300 total yards last week, though he had over 100 rushing. Stafford is a pocket passer who can chew up this secondary for a big yardage day indoors.

Indianapolis Colts vs Los Angeles Rams odds

The Rams have -110 (1.91) odds on the moneyline, implying they have a 52.4% chance to win this game. The Colts also have -110 (1.91) odds, which again is a 52.4% chance of victory.

Colts vs Rams preview – Which offensive line holds up?

The Rams definitely had pass protection issues in Cincinnati, and the Colts could have them in this game due to injuries up front. The quarterback that navigates this better could win the game.

Indianapolis Colts form, news and injuries

The Colts still do not have Jonathan Taylor back at running back, but Zack Moss looked solid last week, and Richardson can give the team a boost on the ground. He will be tested in this one against an elite pass rusher like Aaron Donald. The Colts have also been respectable on defense this year, but Stafford is a different passer from the likes of what they have faced already, so that is another good test.

Indianapolis Colts injury report:

DT DeForest Buckner (Groin) – Questionable
C Ryan Kelly (Concussion) – Out
G Quenton Nelson (Toe) – Questionable
DE Genard Avery (Knee) – Out
WR Ashton Dulin (Knee) – Out
RB Jonathan Taylor (Ankle) – Out
QB Sam Ehlinger (Shoulder) – Questionable
G Danny Pinter (Ankle) – Out
G Jack Anderson (Calf) – Out
CB Isaac Taylor-Stuart (Undisclosed) – Out
OT Bernhard Raimann (Concussion) – Out
TE Jelani Woods (Hamstring) – Out
RB Evan Hull (Knee) – Out
S Daniel Scott (Knee) – Out
OT Jake Witt (Hip) – Out
DE Titus Leo (Undisclosed) – Out

Los Angeles Rams form, news and injuries

The Rams are still without No. 1 wideout Cooper Kupp (hamstring), but Puka Nacua is doing a great job of filling his shoes. The running game is where the Rams need a boost as they only rank 27th in yards per carry. Defensively, the Rams are more than holding their own given the starting lineup before the season looked like Aaron Donald and 10 NPCs.